Cleveland Browns vs. Buffalo Bills projected starting lineup and depth chart for Week 16 | 2025 NFL season

Josh Allen once again proved to be the difference for the Buffalo Bills last week, masterminding a second-half comeback to beat the New England Patriots 35-31 in a game that may ultimately shape the AFC East race. He’ll look to keep that momentum rolling in Week 16 against the Cleveland Browns on Sunday.

Buffalo has won four of its last five games and remains within striking distance of first place in the division. A victory over Cleveland on Sunday would also secure the team a postseason berth.

At 3-11, the Browns are firmly in offseason mode, having lost three straight games and six of their last seven. However, the late-season promotion of Shedeur Sanders has given Cleveland fans something to watch, as the rookie quarterback has brought his playmaking ability to the offense since becoming the starter in Week 12. With three games remaining, Sanders has an opportunity to prove he can be trusted as the team’s quarterback moving forward.

Another major storyline to watch as a Browns fan is Myles Garrett’s pursuit of history. The star pass rusher is just 1.5 sacks away from setting a new NFL single-season record, making Week 16 about more than just the final score for the fans.

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Cleveland Browns vs. Buffalo Bills projected starting lineup for Week 16

Cleveland Browns projected starting lineup

Quarterback Shedeur Sanders of the Cleveland Browns - Source: Getty

Below is the Cleveland Browns' projected lineup on offense against the Buffalo Bills:

Here's a look at Cleveland's likely defensive lineup for Sunday’s clash:

Let's look at the Browns' special teams projected lineup:

Buffalo Bills projected starting lineup

Quarterback Josh Allen of the Buffalo Bills - Source: Getty

Below is the Buffalo Bills' projected lineup on offense against the Cleveland Browns:

Here's a look at Buffalo's likely defensive lineup:

Let's look at the Bills' special teams projected lineup:

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Cleveland Browns vs. Buffalo Bills depth chart

Cleveland Browns depth chart

Here is the Browns’ offensive depth chart.

Cleveland's defensive depth chart is listed below:

Let's look at the Browns’ special teams depth chart:

Buffalo Bills depth chart

Here is the Bills’ offensive depth chart.

Buffalo's defensive depth chart is here below:

Let's look at the Bills’ special teams depth chart:

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How to watch the Browns vs. Bills Week 16 game? TV schedule and live stream details

Sunday’s Week 16 game between the Buffalo Bills and Cleveland Browns will be broadcast across most of the country on CBS, kicking off at 1 p.m. ET. The broadcast team will feature Ian Eagle on play-by-play, J.J. Watt as the color commentator, and Evan Washburn on the sidelines.

For cord-cutters, the game will also be available through live streaming options like DirecTV Stream and FuboTV.

Game details:

Date and Time: Sunday, Dec. 21, at 1 p.m. ET

Location: Huntington Bank Field, Cleveland, Ohio

TV: CBS

Announcers: Ian Eagle, J.J. Watt, Evan Washburn

Live Streaming: Paramount+, FuboTV, DirecTV Stream

Edited by nagpaltusharn25