Los Angeles Rams vs. San Francisco 49ers projected starting lineup and depth chart for Week 10 | 2025 NFL season

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The Los Angeles Rams and San Francisco 49ers are facing off in a battle of NFC West titans. Both teams have Super Bowl ambitions and would want nothing more than a statement win over a divisional rival in Week 10.

With the game set to begin at 4:25 p.m. ET, let's take a look at the starting lineups, depth charts, and how to watch the showdown.

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Los Angeles Rams vs. San Francisco 49ers projected starting lineup for Week 10

Los Angeles Rams' projected starting lineup

These are the Rams' projected starters on offense vs the 49ers:

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Position


Name


WR


Davante

Adams


TE


Tyler

Higbee


LT


Alaric

Jackson


LG


Steve

Avila


C


Coleman

Shelton


RG


Kevin

Dotson


RT


Rob

Havenstein


WR


Jordan

Whittington


WR


Puka

Nacua


QB


Matthew

Stafford


RB


Kyren

Williams


These are the Rams' projected starters on defense vs the 49ers:

Position


Name


OLB


Byron

Young


DE


Braden

Fiske


NT


Poona

Ford


DE


Kobie

Turner


OLB


Jared

Verse


ILB


Omar

Speights


ILB


Nate

Landman


CB


Emmanuel

Forbes Jr.


S


Quentin

Lake


S


Kam

Curl


CB


Cobie

Durant


These are the Rams' projected starters on special teams vs the 49ers:

Position


Name


P


Ethan

Evans


K


Joshua

Karty


H


Ethan

Evans


LS


Alex

Ward


PR


Xavier

Smith


KR


Jordan

Whittington


San Francisco 49ers' projected starting lineup

These are the 49ers' projected starters on offense vs the Rams:

Position


Name


WR


Jauan

Jennings


LT


Trent

Williams


LG


Spencer

Burford


C


Jake

Brendel


RG


Dominick

Puni


RT


Colton

McKivitz


TE


George

Kittle


WR


Kendrick

Bourne


RB


Christian

McCaffrey


FB


Kyle

Juszczyk


QB


Brock

Purdy


These are the 49ers' projected starters on defense vs the Rams :

Position


Name


LDE


Mykel

Williams


LDT


Kevin

Givens


RDT


Jordan

Elliott


RDE


Sam

Okuayinonu


SAM


Luke

Gifford


MIKE


Tatum

Bethune


WILL


Dee

Winters


LCB


Renardo

Green


RCB


Deommodore

Lenoir


NB


Upton

Stout


FS


Ji'Ayir

Brown


SS


Malik

Mustapha


These are the 49ers' projected starters on special teams vs the Rams:

Position


Name


P


Thomas

Morstead


K


Eddy

Piñeiro


H


Thomas

Morstead


PR


Skyy

Moore


KOR


Skyy

Moore


LS


Jon

Weeks


Los Angeles Rams vs. San Francisco 49ers depth chart

Los Angeles Rams' depth chart

This is the Rams' projected depth chart on offense vs the 49ers:

Position


First


Second


Third


Fourth


WR


Davante

Adams








TE


Tyler

Higbee


Colby

Parkinson


Davis

Allen


Terrance

Ferguson


LT


Alaric

Jackson


D.J.

Humphries


David

Quessenberry




LG


Steve

Avila


Justin

Dedich






C


Coleman

Shelton


Beaux

Limmer






RG


Kevin

Dotson








RT


Rob

Havenstein


Warren

McClendon Jr.






WR


Jordan

Whittington


Xavier

Smith






WR


Puka

Nacua


Konata

Mumpfield






QB


Matthew

Stafford


Jimmy

Garoppolo


Stetson

Bennett IV




RB


Kyren

Williams


Blake

Corum


Jarquez

Hunter




This is the Rams' projected depth chart on defense vs the 49ers:

Position


First


Second


Third


Fourth


OLB


Byron

Young


Josaiah

Stewart






DE


Braden

Fiske


Larrell

Murchison


Desjuan

Johnson




NT


Poona

Ford


Ty Hamilton






DE


Kobie

Turner


Tyler

Davis






OLB


Jared

Verse


Nick

Hampton






ILB


Omar

Speights


Shaun

Dolac






ILB


Nate

Landman


Troy

Reeder






CB


Emmanuel

Forbes Jr.


Darious

Williams


Roger

McCreary




S


Quentin

Lake


Kamren

Kinchens






S


Kam

Curl


Jaylen McCollough






CB


Cobie

Durant


Josh

Wallace






This is the Rams' projected depth chart for special teams vs the 49ers:

Position


First


Second


Third


Fourth


P


Ethan

Evans








K


Joshua

Karty








H


Ethan

Evans








LS


Alex

Ward








PR


Xavier

Smith


Konata Mumpfield






KR


Jordan

Whittington


Blake

Corum






San Francisco 49ers depth chart

This is the 49ers' projected depth chart on offense vs the Rams:

Position


First


Second


Third


Fourth


WR


Jauan

Jennings


Demarcus

Robinson






LT


Trent

Williams








LG


Spencer

Burford








C


Jake

Brendel


Matt

Hennessy






RG


Dominick

Puni








RT


Colton

McKivitz


Austen

Pleasants






TE


George

Kittle


Luke

Farrell


Jake

Tonges




WR


Kendrick

Bourne


Skyy

Moore


Jordan

Watkins




RB


Christian

McCaffrey


Brian

Robinson Jr.


Isaac

Guerendo


Jordan

James


FB


Kyle

Juszczyk








QB


Brock

Purdy


Mac

Jones


Adrian

Martinez




This is the 49ers' projected depth on defense vs the Rams:

Position


First


Second


Third


Fourth


LDE


Mykel

Williams


Bryce

Huff






LDT


Kevin

Givens


Kalia

Davis


Alfred

Collins




RDT


Jordan

Elliott


C.J.

West






RDE


Sam

Okuayinonu








SAM


Luke

Gifford


Curtis

Robinson






MIKE


Tatum

Bethune








WILL


Dee

Winters


Nick

Martin






LCB


Renardo

Green


Chase

Lucas






RCB


Deommodore

Lenoir


Darrell

Luter Jr.






NB


Upton

Stout








FS


Ji'Ayir

Brown


Marques

Sigle


Siran

Neal




SS


Malik

Mustapha


Jason

Pinnock






This is the 49ers' projected depth chart for special teams vs the Rams:

Position


First


Second


Third


Fourth


P


Thomas

Morstead








K


Eddy

Piñeiro








H


Thomas

Morstead








PR


Skyy

Moore


Jordan

Watkins






KOR


Skyy

Moore


Brian

Robinson Jr.


Isaac

Guerendo




LS


Jon

Weeks








How to watch Los Angeles Rams vs San Francisco 49ers? TV channel and live stream details for the Week 10 game

The San Francisco 49ers enter Week 10 with a 6-3 record. Kyle Shanahan's side has dealt with numerous injuries to key players, but remains on course to make this season's playoffs after missing out in the previous campaign.

Their Week 10 game against the Los Angeles Rams is a rematch of their Week 5 contest. The 49ers won that game in overtime, and their fans will appreciate a similar outcome in Sunday's showdown.

The Los Angeles Rams remain one of the NFC's biggest Super Bowl contenders. Sean McVay has led his troops to wins in a variety of ways in the ongoing campaign.

The Rams are facing the 49ers for the second time this season. They're looking to avenge their Week 5 26-23 overtime loss. It's a game that could have significant ramifications on the divisional table come January.

Here's what you need to know about watching the 49ers vs. Rams Week 10 game:

  • Date: Sunday, November 9, 2025
  • Livestream: FuboTV and DAZN
  • Time: 4:25 p.m. ET
  • TV Channel: Fox
  • Venue: Levi's Stadium in Santa Clara, California

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Edited by Nick Igbokwe

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