49ers vs. Colts prediction and fantasy outlook for Week 16 MNF feat. Philip Rivers, Christian McCaffrey, and more

The San Francisco 49ers and Indianapolis Colts are set to battle on one of the last editions of Monday Night Football in 2025. It is also a contest that could determine whether you will reach the fantasy football championship. There's a lot on the line, and the addition of Philip Rivers complicates the game immensely.

Here's a look at what to expect to help clear the air on what the former Los Angeles Chargers franchise quarterback's return could mean for the game and your fantasy football team.

49ers vs Colts prediction

Christian McCaffrey at Tennessee Titans v San Francisco 49ers - NFL 2025 - Source: Getty

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San Francisco and Indianapolis have shaky defenses at best. Indianapolis surrendered 36 points to the division rival Jacksonville Jaguars and face the next best thing in Week 16.

Between Christian McCaffrey, Jauan Jennings, and George Kittle, Indianapolis will have its hands full. Don't expect the Colts to no-show, however. Jonathan Taylor alone will make things competitive. However, while Philip Rivers' return story has been a bright spot in headlines, suddenly getting thrust into a playoff situation in prime time two games into one's return will be too much to handle.

Rivers and the Colts will lose the contest 28-14.

49ers vs Colts fantasy picks

Brock Purdy at Tennessee v San Francisco - NFL 2025 - Source: Getty

San Francisco's usual suspects are likely to perform at a high level. You can depend on Christian McCaffrey, George Kittle, Jauan Jennings, and potentially Kendrick Bourne and Brock Purdy to deliver in a must-have game.

As for the Indianapolis Colts, however, the lone name to trust is Jonathan Taylor. If you're in a pinch, you can risk starting Philip Rivers against the banged-up 49ers defense if you only need about 15 points.

Where to watch San Francisco 49ers vs Indianapolis Colts on cable

Philip Rivers at Indianapolis Colts at Seattle Seahawks - Source: Imagn

According to the official Indianapolis Colts schedule, you can catch the game on ESPN, ABC, ESPN2, ESPN Deportes, and Disney+.

If you don't have cable, you are in luck. With the game broadcast taking place on ABC, you can use an over-the-air antenna to watch the action without a cable subscription. The ManningCast will take place on ESPN2, which will allow you to see the game with Eli and Peyton Manning.

The commentary might be particularly entertaining as Peyton was a division rival against Philip Rivers during his time with the Denver Broncos between 2012 and the end of the 2015 season.

Edited by Ian Van Roy