San Francisco 49ers vs. Chicago Bears predictions, odds, and picks for Week 17 SNF clash

The 11-4 Chicago Bears are traveling to face the 11-4 San Francisco 49ers in a spectacle that all NFL fans have a reason to watch. While Bears fans and 49ers fans clearly will have more of a stake in the contest than others, it only takes a few bets to make oneself as invested as anyone.

Here's a betting guide to the contest, which includes everything you need to know, including picks, odds, and predictions.

San Francisco 49ers vs. Chicago Bears: Game Details

Game: Chicago at San Francisco

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Date & Time: Sunday, Dec. 28, 2025, at 8:20 PM EST

Venue: Levi's Stadium in Santa Clara, California

San Francisco 49ers vs. Chicago Bears: Betting Odds (via BetMGM)

Spread

Chicago (+3.5)

San Francisco (-3.5)

Moneyline

Chicago (+155)

San Francisco (-190)

Total

Over/Under (51.5)

San Francisco 49ers vs. Chicago Bears: Picks

The safest bet in the game is to take the Brock Purdy anytime touchdown. Purdy is the hottest quarterback in the league at the moment, throwing for 13 touchdowns in his last five games. He has also thrown for at least one touchdown in every game he has played in this season.

The other safest bet will be taking the Christian McCaffrey anytime touchdown. McCaffrey has scored a touchdown in every game since Nov. 16. McCaffrey is the heartbeat of the offense and is about as safe as it gets.

San Francisco 49ers vs. Chicago Bears: NFL Injury Report

San Francisco

CB Renardo Green (Neck) - Out

TE George Kittle (Ankle) - Questionable

WR Ricky Pearsall (Knee, Ankle) - Questionable

QB Kurtis Rourke (Knee) - Out

Chicago

CB Nick McCloud (Illness) - Out

WR Rome Odunze (Foot) - Out

CB Josh Blackwell (Illness) - Questionable

CB Nashon Wright (Hamstring/Illness) - Questionable

LB T.J. Edwards (Glute) - Questionable

SAF C.J. Gardner-Johnson (Knee) - Questionable

G Luke Newman (Foot) - Questionable

San Francisco 49ers vs. Chicago Bears: Head-to-Head

Despite having a rivalry that dates back to 1950, Chicago and San Francisco have an all-time record that is remarkably close. San Francisco leads the series at 36-33-1. Neither team has won back-to-back matchups since Chicago defeated San Francisco in the 2005 and 2006 seasons.

Most recently, Brock Purdy's San Francisco defeated Chicago by a score of 38-13 in a contest that took place in San Francisco.

San Francisco 49ers vs. Chicago Bears: Prediction for Week 17

With both teams alternating wins in recent years, huge pressure on San Francisco to stay alive in the NFC West race, and Chicago coming off a loss in the most recent matchup between the two teams, expect Chicago to pull a win out.

The pressure of the moment will get to Purdy in the closing moments of the contest, with Caleb Williams answering blow for blow, winning the contest 31-28.

Edited by Ian Van Roy