Philadelphia Sixers vs Boston Celtics Preview and Prediction - Oct. 22 | 2025-26 NBA Season

The Philadelphia Sixers will be on the road to face the Boston Celtics for their 2025-25 season opener. It is one of the 12 games scheduled for Wednesday.

The Sixers finished No. 13 in the Eastern Conference last season with a 24-58 record. They won once in their last 15 matchups last season.

The Celtics, on the other hand, failed to defend their 2024 title and ended the 2024-25 season second in the Eastern Conference with a 61-21 record. Their season ended with a conference semifinals 4-2 loss to the New York Knicks.

Philadelphia stuck with their core of Joel Embiid and Paul George, despite a disappointing 2024-25 season plagued with injuries. They acquired Quentin Grimes and Jared Butler from the Dallas Mavericks and Washington Wizards respectively.

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The Celtics made significant changes to their roster during the summer. They traded Jrue Holiday to the Portland Trail Blazers for Anfernee Simons and Kristaps Porzingis to the Atlanta Hawks.

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Philadelphia Sixers vs. Boston Celtics game details

The Sixers-Celtics game is scheduled for 7:30 p.m. ET at TD Garden in Massachusetts, Boston. The matchup will air on TV on NBC Sports (Philadelphia and Boston) and radio via 97.5 The Fanatic and the 76ers Mobile App. Streaming via Fubo.

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Philadelphia Sixers vs. Boston Celtics betting lines

Moneyline: Sixers (+130) vs. Celtics (-155)

Spread: Sixers (+3.5) vs. Celtics (-3.5)

Total: (O/U): Sixers (o229.0) -110 vs. Celtics (u229.0) -110

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Philadelphia Sixers vs. Boston Celtics preview

The Celtics have a better head-to-head record against the Sixers. They have met 471 times and Boston leads with a 273-198 record. In their last five games, the Celtics have dominated with a 4-1 record.

Their last matchup was on March 6 with the Celtics winning 123-105 at home. Celtics forward Jayson Tatum recorded 35 points, seven rebounds and two assists. Sixers forward Kelly Jr. Oubre finished with 27 points, five rebounds and six assists.

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Philadelphia Sixers vs. Boston Celtics predicted starting lineups

Sixers

PG - Tyrese Maxey | SG - VJ Edgecombe | SF - Kelly Oubre | PF - Adem Bona | C - Joel Embiid

Celtics

PG: Derrick White | SG: Anfernee Simons | SF: Jaylen Brown | PF: Sam Hauser | C: Neemias Queta

Note: The starting lineups could still change ahead of tipoff.

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Philadelphia Sixers vs. Boston Celtics betting tips

Joel Embiid has an over/under of 24.5 points via FanDuel. He averaged 23.8 ppg in his last 10 games last season, and the safe bet is the over.

Meanwhile, Jaylen Brown has an over/under of 23.5 points via FanDuel. He averaged 22.7 ppg in his last 10 games last season, and the safe bet is the over.

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Philadelphia Sixers vs. Boston Celtics prediction

The Celtics are the bookmaker favorites to win this matchup. With a 60.8% win percentage compared to the Sixers’ 43.5%.

Edited by Ubong Richard