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Week 9 in the NFL was a bit nuts with upsets from even the biggest of underdogs, including the Packers falling to the Panthers at Lambeau, and the Steelers handing the Colts only their second loss of the season.
As the schedule moves into November, the second half of the 2025 regular season is bound to have its share of surprises.
Despite the rough, shocking results, here's diving into another fearless forecast with picks and predictions against the spread for the follow-up 14-game slate of Week 10:
(Odds courtesy of Caesars Sportsbook)
POWER RANKINGS: Bills, Rams back near top; Packers, Chiefs slide into Week 10
NFL picks against the spread for Week 10
Game of Midweek: Raiders at Broncos (-9.5, 41.5 o/u)
Thursday 8:15 p.m. ET, Amazon Prime Video
The Broncos are difficult to stop at home because that's where Bo Nix and the offense perform best. They also proved their defense remains nasty all-around when not having Patrick Surtain II in pass coverage. The Raiders worked until the end of overtime in Week 9 and will come in weary for a tough all-around game with one Super Bowl-winning coach (Sean Payton) getting the better of the other (Pete Carroll).
Pick: Broncos win 30-17 and cover the spread.
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Game of the Week: Eagles at Packers (-2.5, 44.5 o/u)
Monday 8:15 p.m. ET, ESPN/ABC
The Eagles have gotten their passing groove back with Jalen Hurts and then saw Saquon Barkley go back to running wild before the bye. They are 4-0 after the bye under Nick Sirianni, while the Packers are still picking up the pieces from the Panthers disaster at home. The running of Hurts and Barkley keeps Micah Parsons and the pass defense at bay while Jordan Love and his offense stay slumping.
Pick: Eagles win 24-17.
MORE: How Packers' loss to Panthers shakes up NFC North standings
Lock of the Week: Bears (-3.5, 48.5 o/u) over Giants
Sunday 1 p.m. ET, Fox
The Bears' offense is hitting on all cylinders with more key personnel being unlocked for Ben Johnson to facilitate the running game and also give Caleb Williams more juice in the passing game. That's good news for facing a reeling Giants defense that cannot stop run or downfield pass. Jaxson Dart again won't have enough around him on the road.
Pick: Bears win 27-17 and cover the spread.
Upset of the Week: 49ers (+3.5, 49.5 o/u) over Rams
Sunday 4:25 p.m. ET, Fox
This could have been the "game of the week" between the NFC West archrivals in the battle to win the division over each other and the surprise front-running Seahawks. The 49ers rallied to win the first meeting with Mac Jones and might have Brock Purdy back at QB to duel a red-hot Matthew Stafford. Kyle Shanahan keeps up outwitting Sean McVay.
Pick: 49ers win 27-24.
Falcons at Colts (-5.5, 48.5 o/u)
Sunday 9:30 a.m. ET, NFL Network (from Berlin, Germany)
The Colts will welcome this respite overseas after being roughed up in Pittsburgh. They will hope the sack and turnover mess with Daniel Jones was a fluke and now they need to get Jonathan Taylor's running right back on track. Atlanta is No. 23 vs. the run, which also helps. Indianapolis finds his scoring speed again while the Falcons go back to cooling off with Drake London in Berlin.
Pick: Colts win 31-21 and cover the spread.
MORE: Parker Romo's missed extra point ruins Drake London's big day vs. Patriots
Bills (-8.5, 50 o/u) at Dolphins
Sunday 1 p.m. ET, CBS
The Bills are rolling and the Dolphins are reeling. James Cook won't be slowed down from his march toward the league rushing title while there seems to be less chance of De'Von Achane getting the needed offensive support to keep up. Josh Allen makes sure this rematch isn't close.
Pick: Bills win 34-17 and cover the spread.
MORE: Why Dolphins won't move on from Mike McDaniel in middle of season
Ravens (-3.5, 48 o/u) at Vikings
Sunday 1 p.m. ET, Fox
Lamar Jackson is back to make the Ravens' offense sizzle and they have found some defensive answers. J.J. McCarthy provided a similar spark to the Vikings. This should be a high-scoring game with plenty of purple points. Baltimore's sudden steadiness plus Minnesota's inconsistency leads to a predictable result.
Pick: Ravens win 27-24 but fail to cover the spread.
Browns at Jets (-2, 37 o/u)
Sunday 1 p.m. ET, CBS
The Browns and Jets are both coming off merciful byes. This is a manageable matchup for Myles Garrett and the better defensive team coming into the matchup. The Browns can contain the run while also getting the more impactful running game on the road.
Pick: Browns win 20-17.
Patriots at Buccaneers (-2.5, 48.5 o/u)
Sunday 1 p.m. ET, CBS
The "Tom Brady Bowl" will be fun with his two former teams being set at quarterback with the oddly similar-named Drake Maye and Baker Mayfield. Maye keeps pushing New England's new-look passing game along and Mayfield is doing it with a young wave of backs and receivers. Tampa Bay escapes in another shootout with Mayfield late.
Pick: Buccaneers win 27-24 and cover the spread.
Saints at Panthers (-5, 40 o/u)
Sunday 1 p.m. ET, CBS
Tyler Shough is showing something for the Saints. Now it's up to their defense to keep them in the game so he can be a competitive passer. The Panthers are all over the place but the running game and defense are settling in as their strong identities. Shough and Bryce Young play through some goo goo much in a low-scoring game.
Pick: Panthers win 23-20 but fail to cover the spread.
MORE: How Tyler Shough earned starting role over Spencer Rattler
Jaguars at Texans (-1.5, 38 o/u)
Sunday 1 p.m. ET, CBS
The Jaguars and Texans both have defenses who will try to take over for some big plays to help the offenses. C.J. Stroud may not be cleared from his concussion to duel gritty Trevor Lawrence. The three phases for Jacksonville as a whole a little bit better and it reflects on the scoreboard.
Pick: Jaguars win 20-17..
Cardinals at Seahawks (-7, 44.5 o/u)
Sunday 4:05 p.m. ET, CBS
The Seahawks are finding their offensive rhythm with a lot more passing than expected with growing confidence in Jaxon Smith-Njigba, plus Sam Darnold getting the ball to all of his receivers for big plays. The Cardinals have become an injury-riddled, oft-stagnant mess in relation.
Pick: Seahawks win 30-14 and cover the spread.
MORE: Sam Darnold enjoys monster day in dominant win over Commanders
Lions (-8.5, 49.5 o/u) at Commanders
Sunday 4:25 p.m. ET, Fox
The Lions get a break here against a Dan Quinn defense wilting against the pass and giving up big plays on top of being gashed by the run often. That leaves no chance for Marcus Mariota to outduel Jared Goff with his weaponry well shorthanded.
Pick: Lions win 34-17 and cover the spread.
MORE: Ranking best options for Commanders to replace Jayden Daniels
Steelers at Chargers (-3, 44.5 o/u)
Sunday 8:20 p.m. ET, NBC/Peacock
This would be another "game of the week" type matchup. The Steelers' defense came through at home but the road is tougher against Justin Herbert. But the Chargers will get caught getting too one-dimensional and succumb more to the pressure with Herbert getting hit more than Aaron Rodgers.
Pick: Steelers win 27-23.
Stats of the Week
- Week 9 record straight up: 8-5
- Week 9 record against the spread: 5-8
- 2025 season record straight up: 89-43
- 2025 season record against the spread: 66-66
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