Nationals vs. Padres: Game 3 prediction, odds, injuries and picks - June 25, 2025

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The Washington Nationals will take on the San Diego Padres on Wednesday for the third and final game of the series at Petco Park. Washington is at the bottom of the NL East with a 33-47 record, while San Diego is 43-36 and third in the NL West.

Let's look at the odds and how the action migh play out in the series finale.

Nationals vs Padres prediction

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Taking the mound for the Nationals is ace MacKenzie Gore, who has been great this season. He has a 3-7 record, along with a 3.19 ERA and 123 strikeouts.

 GettyMackenzie Gore in action against the Los Angeles Dodgers - Source: Getty

Offensively, James Wood, C.J. Abrams, Luis Garcia and Nathaniel Lowe have been impressive for the Nationals.

For the Padres, righty Nick Pivetta will start. Just like Gore, he has also been solid this year, boasting a 7-2 record, along with a 3.64 ERA and 91 strikeouts.

At the plate, Manny Machado, Jackson Merrill, Fernando Tatis Jr. and Gavin Sheets have led the way for the Friars.

Being the better team this year and playing at home, San Diego should have enough quality to record an important win on Wednesday to clinch the series.

Prediction: San Diego Padres 5, Washington Nationals 3

Odds

Money line: Washington Nationals +125, San Diego Padres -147

Run line: San Diego -1.5 (+133), Washington +1.5 (-179)

Total runs: Over 6.5 (-182), Under 6.5 (+135)

Injury report

Nationals injuries

  • Dylan Crews: 10-day IL (Back)
  • Paul DeJong: 10-day IL (Face)
  • Keibert Ruiz: 10-day IL (Head)
  • Orlando Ribalta: 15-day IL (Bicep)
  • Andrew Chafin: 15-day IL (Hamstring)
  • Derek Law: 15-day IL (Forearm)
  • Josiah Gray: 60-day IL (Elbow)
  • DJ Herz: 60-day IL (Elbow)
  • Mason Thompson: 60-day IL (Elbow)

Padres injuries

  • Logan Gillaspie: 15-day IL (Oblique)
  • Michael King: 15-day IL (Shoulder)
  • Yu Darvish: 60-day IL (Elbow)
  • Jhony Brito: 60-day IL (Forearm)
  • Joe Musgrove: 60-day IL (Elbow)
  • Ryan Bergert: day-to-day (Elbow)

Expert's picks

Most Nick Pivetta starts have resulted in wins for San Diego, and that trend should continue on Wednesday. Although the Nationals are also sending their ace to the mound, the Friars' superior offense should ultimately take care of business.

Money line: San Diego Padres -147

Run line: San Diego -1.5 (+133)

Total runs: Over 6.5 (-182)

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About the author

Raghav Mehta

Raghav Mehta is a baseball journalist at Sportskeeda awaiting results for a Bachelor's in Journalism from Delhi University. He enjoys highlighting the key battles between players at different stages of the game and analyzing the decisive moments upon which they hinge.

One of Raghav's favorite moments, which underscores this, was the Shohei Ohtani vs. Mike Trout clash in the 2023 WBC, where two of baseball's best players faced off against each other in the 9th inning. With the score 3-2 to Japan, Shohei eventually got the strikeout, which was absolute cinema.

Raghav is a Baltimore Orioles fan and is enjoying watching such an exciting young team compete at the top in a very competitive division.

Raghav has loved watching sports for as long as he can remember and realized he was pretty decent at writing his thoughts down at around the age of 14. Combining the two meant he had something he would enjoy doing every day, and he had identified that well before going to college.

Aside from work, Raghav enjoys playing sports, working out and watching movies.

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Edited by Victor Ramon Galvez

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