Is aging optional? We pressed experts on the best NAD+ supplements to biohack aging

Are you NAD-ing?

Well, if you aren’t, someone else is. Most likely your favorite movie star or TikToker. 

Perhaps you remember NAD supplements from an episode of “The Kardashians” when Hailey Bieber told Kendall Jenner, “I’m going to NAD for the rest of my life, and I’m never going to age,” as she was hooked up to a NAD catalyzed. Or maybe Joe Rogan discussing his supplement routine on an episode of his podcast?

If that doesn’t ring a bell, you may have heard about the buzzy wellness trend from the cohort of other health-conscious celebrities touting its benefits.

The Post has consulted multiple experts to break down the craze behind the best NAD supplements, known to boost Nicotinamide Adenine Dinucleotide (NAD) levels, a vital compound for anti-aging.

“These supplements work by increasing the availability of NAD in your cells, supporting essential processes like energy, metabolism, brain function, and cell regeneration,” explained Dr. Halland Chen — colloquially known simply as Dr. Halland — a functional medicine practitioner in New York City.

“Ultimately, NAD supplements aim to slow the aging process, increase vitality, and support overall well-being,” added Halland.

So yes, NAD-ing can be a verb — at least, according to some anti-aging supplement brands, like Wonderfeel. And it’s not just for the stars; we normies can NAD, too.

By boosting NAD levels, Halland has explained that these supplements can help enhance mitochondrial function, promote DNA repair, reduce inflammation, and improve cognitive performance.

A common question about raising NAD levels is whether to take NAD supplements directly or opt for precursors like NR or NMN supplements. NAD itself cannot easily enter cells and has limited effect as a supplement. In contrast, NMN acts as a precursor that crosses into cells more efficiently, making it a more effective choice for naturally boosting NAD levels.

NMN and NR are both NAD precursors, but NMN has an extra phosphate group and is the immediate precursor to NAD. According to a study published by the National Institute of Health (NIH), “​​various experimental studies found that NMN improved cardiac function whereas NR improved mitochondrial function in muscle, liver, and brown adipose tissue.”

Despite NAD supplements only going mainstream in the last few years, there is already research supporting their efficacy and several trusted brands on the market, like Wonderfeel, TRU NIAGEN, Life Extension, Thorne, and more.

For answers to all your questions about the latest craze in preserving youth, we’ve consulted Halland, Dr. Andrew Salzman, and Registered Dietician Caroline Thomason. We’ve also collected publicly available statements from Dr. Mark Hyman.

Read on for a lesson in NAD-ing and browse our guide to choosing the best supplements for your goals.

Best NAD Precursor Overall: Wonderfeel Youngr NMN

Wonderfeel

“Wonderfeel Youngr NMN’s 900 mg dose is impressive because it offers a stronger boost to NAD+ levels compared to many other supplements,” shared Halland. “This higher dose is ideal for those who want more noticeable effects, like improved energy, better focus, and quicker recovery, making it a top choice for more serious anti-aging support.”

Halland also points out that Wonderfeel’s multi-targeted formulation makes it stand out from competitors. He suggests that adding resveratrol and ergothioneine, known as the longevity vitamin, works well with NMN to amplify the benefits, enhancing cellular repair, methylation, and overall vitality.

“Providing NMN alone without addressing oxidative stress is only half the story,” explained Salzman, who is a well-recognized drug expert who formulated Wonderfeel Youngr. “By including targeted antioxidants — especially those in our formula — we nurture the cells, amplify NMN’s efficacy, and enhance its overall impact.”

Wonderfeel Youngr starts at $73 for a subscription and $88 for a one-time purchase. “While it’s a bit pricier, the robust formulation justifies the cost, making it worth the investment if you’re aiming for more substantial results,” Halland explained.

Dose: 900 mg NMN

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Editor’s Pick: Elysium Basis

Elysium Health

Elysium Basis is a scientifically formulated supplement designed to support cellular health and promote healthy aging. Developed by Dr. Leonard Guarente, a leading researcher in the field of aging and the chief scientist at Elysium Health, Basis combines two powerful ingredients: Nicotinamide Riboside (NR) and Pterostilbene (PT).

Nicotinamide Riboside (NR) is a naturally occurring form of vitamin B3 and serves as a highly efficient precursor to NAD+. NAD+ plays a key role in cellular energy production, DNA repair, and maintaining overall cellular function. By providing NR, Basis helps increase NAD+ levels, which tend to decline with age.

Pterostilbene (PT) is a potent polyphenol and a derivative of resveratrol, known for its antioxidant properties. PT helps protect cells from oxidative stress and supports the activity of sirtuins, proteins that play a role in aging and longevity. The combination of NR and PT in Basis is designed not only to boost NAD+ levels but also enhance the overall effectiveness of sirtuins.

Clinical studies have shown that taking Basis can increase and sustain NAD+ levels by 40%, leading to several potential benefits, including healthy aging promotion by supporting cellular function and energy production. Additionally, it has been shown to boost cellular energy, help protect DNA, support skin health, and enhance muscle function.

“As a primary care physician… I recommend Basis to all my patients looking to improve their overall long-term health.” – Richard Dinsdale, M.D., Elysium customer since 2016.

Dose: 250 mg NR and 50 mg of Pterostilbene

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Best NAD on Amazon: TRU NIAGEN NAD+ Booster

Tru Niagen

“Tru Niagen PRO NAD+ uses 500 mg of nicotinamide riboside (NR), which is backed by extensive clinical research for increasing NAD+ levels, improving mitochondrial function, and supporting brain health,” shared Halland.

Potency is a big plus for Halland, who suggested that Tru Niagen could deliver more noticeable effects like sustained energy, sharper mental clarity, and better cellular repair when compared to standard doses. Amazon reviewers seem to agree, with almost 10,000 customers giving it a 5-star review.

“It’s also third-party tested for purity, so you can trust its safety and quality,” added Halland. “While it’s a bit more expensive than some other options, the stronger dose and solid clinical backing make it a standout choice for those committed to serious, long-term NAD+ supplementation.”

Dose: 500 mg NR

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Best NAD Powder: BulkSupplements.com NAD Powder

Amazon

NAD can also be found in powder form for those who prefer mixing supplements into liquids or smoothies.

“I like that you can adjust the dose to fit your needs, making it a great option if you want to start small or go big. It’s super pure and cost-effective, which is perfect if you’re a regular user looking to save some cash,” said Halland.

The powder form is another good option for those who don’t like pills. However, there are a couple of downsides, according to the expert.

“Just a heads-up, though — you’ll need a good scale for accurate dosing, and the taste isn’t the best, but if you can handle that, it’s a strong pick for boosting NAD+.”

Dose: 500 mg NAD+

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Best Low-Dose NAD: Life Extension NAD+ Cell Regenerator and Resveratrol Elite

Amazon

Life Extension Cell Regenerator delivers 300 mg of NR per capsule, which, according to Halland, is a clinically backed dose for effectively increasing NAD levels, improving mitochondrial function, and supporting metabolic health.

“While this dose is solid, those seeking more dramatic effects might benefit from a higher dosage, like 400 to 500 mg. The supplement is third-party tested, ensuring its purity and free from contaminants, which adds trustworthiness,” he said.

While Halland admits this formula is expensive, he says that the reliable formulation, focus on quality, and ability to improve cellular energy make it a worthwhile option for those serious about NAD support.

Dose: 300 mg NR

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Best NAD Patches: Barrière NAD+ YOUth Repair Patches

Barrière Logo Search

Ready to try the next thing in the world of NAD? Barrière has launched NAD+ YOUth Repair Patches, available in latex-free element symbols that you can stick anywhere. Each patch contains 9mg of nicotinamide riboside (NR), the NAD+ precursor.

According to the company, the patches deliver steady, all-day support through your skin, bypassing the gut for efficient absorption. This more gradual delivery method could also help minimize potential side effects, according to Barrière’s Wellness Advisor, Dr. Sogol Ash.

While some experts still question how effectively NAD can be absorbed through the skin barrier, NAD patches still offer a promising alternative for anyone who is looking for a fun, pill-free, IV-free way to support cellular energy and healthy aging.

The directions are simple. Simply pick, peel, and stick on two patches per day, every other day, to get your optimal dose. They can be applied anywhere, besides the face.

Dose: 18 mg NR

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Best Value NAD Supplement: Wonderfeel NMN Capsuls

Wonderfeel

“Wonderfeel NMN Capsuls deliver nicotinamide mononucleotide (NMN) in a straightforward capsule form,” stated Halland.

These Capsuls are a wonderful starting point for individuals beginning on their anti-aging health journey. A single pill contains 500 mg NMN, but one serving (two pills) is 1000 NMN, which makes the Capsuls a great stackable option. Users can start out at a lower dose and choose to increase it when they’re ready.

Potency is a huge draw, but the 99% purity is also a major selling point of this formula, according to Halland.

“The straightforward formulation without fillers or extras makes it ideal for those wanting a simple, targeted NAD+ boost. The price is moderate for NMN products, making it more accessible while still delivering quality,” Halland added.

While the price is higher, Capsuls provides the most cost-effective NMN supplement, offering consumers the best value per gram of NMN compared to other brands.

Dose: 1000 mg NMN

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Best NAD for Immune Support: TRU NIAGEN Immune Support Supplement

Amazon

Your immune system changes as you age. True Niagen wanted to create a supplement with proven immune system defense, so they created the TRU NIAGEN Immune Support Supplement.

Powered by the award-winning ingredient, Niagen has been shown to boost NAD+ levels, an essential compound your cells rely on for energy, focus, cellular health, and recovery. Niagen is backed by over 300 published scientific studies, as well as hundreds of global research collaborations.

Thousands of reviewers have spoken about their benefits, from improved endurance and energy to immune support and longevity. Some have even claimed that Tru Niagen is the reason they haven’t had to take a sick day in years.

Miska Salemann

New York Post Review: I’ve only been taking Tru Niagen for a couple of weeks, but the results are already impressing me. The 4 a.m. brain fog? Gone. Typical mid-day crash? Dissappeared. Constant need for caffeine? Barely there. With immune-boosting nutrients like vitamins D, C, and zinc, I’m also confident I’m getting the extra support I need to stay healthy during one of the busiest times of the year. If you’re also juggling long shifts and balancing a tight schedule, Tru Niagen may be exactly what your body needs, too. I’ve taken plenty of supplements, but this is one I’ve found that has an effect on my day-to-day life.

Dose: 150 mg N

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Best High-Dose NAD: Wellness Lab SRX NAD+ High-Dose

Amazon

“Wellness Lab SRX NAD+ High-Dose packs a punch with its high-strength NMN formula, designed for those looking to level up their NAD+ fast,” shared Halland.

Halland explained that the focus on purity and third-party testing adds reassurance about safety, which is always a win. The potent dose is ideal for people who want noticeable results, like increased energy and sharper focus. However, 1500 mg NMN could be a bit much for someone new to NMN supplements.

“The strong formulation makes it worth considering if you’re aiming for serious anti-aging support,” he concluded.

Dose: 1500 mg NMN

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Best NAD with Clear Labeling: THORNE NiaCel 400

Amazon

“Thorne Niacel 400 features nicotinamide riboside (NR), a well-researched precursor for boosting NAD+ levels. I like that it’s formulated to provide a 400 mg dose, which is stronger than many other options and aligns with clinical recommendations for effective cellular support,” said Halland.

For someone looking for a NAD supplement from a brand they can recognize, Thorne may be the right choice. According to Halland, the brand is trusted by many customers. The labeling is clear and easy to read.

“Thorne is known for its high purity and rigorous third-party testing, ensuring safety and quality. While the price is a bit on the higher side, the product’s reputation, simple packaging, and reliable results make it a strong choice for NAD supplementation.”

Dose: 500 NR

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Best Liposomal NAD: Orgabay Liposomal NAD+ Supplement 500 mg

Amazon

“Orgabay uses 500 mg of NAD+ combined with 250 mg of trimethylglycine (TMG), which supports methylation and enhances cellular health,” said Halland.

This formula stands out from some others due to the addition of liposomes, which may protect NAD from erosion during delivery to the intestinal wall. While some experts have mixed opinions on liposomal delivery, Halland believes that it improves absorption and bioavailability, making it more effective than standard oral supplements.

“It’s non-GMO, soy-free, and free from artificial additives, ensuring good purity,” Halland added. “The strong dose and improved absorption make it a solid choice for those seeking better energy and longevity benefits.”

Dose: 500 mg NAD

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Best NAD Shots: Happy Aging NAD+ Longevity shots

Happy Aging

If you’re not sold on NAD patches or pills, you might want to consider NAD shots.

Happy Aging delivers a 100 mg dose of NR in the form of a small glass bottle. Blended with superfoods like spinach leaf and white currant, as well as ceramides and grape seed extract, Happy Aging’s Longevity Shots deliver 8 key ingredients designed to slow down aging, boost energy, and cognition.

The brand recommends taking two shots per week to keep NAD levels elevated. All you have to do is give them a shake and enjoy, with or without food. Reviewers are generally pleased, with 74% reporting being happy with the overall results, and 97% satisfied with how easy these shots are to take.

Simply drink two shots per week — either straight from the bottle or over ice with sparkling water. Enjoy with or without food. Shake well before drinking.

Dose: 100 mg NR

Miska Salemann

New York Post Review: Not sold on NAD? Neither was I. That is, until I gave these Longevity Shots a real shot. They deliver a pretty reasonable dose of NR (100 mg) and resveratrol (220 mg), and are surprisingly delicious. A little fruity, light, and refreshing — you definitely won’t have to plug your nose and chug. I found that they mix well into drinks, too. For anyone juggling a busy schedule (or those who simply detest taking pills), these NAD shots are a welcome solution. As to the results, I may have noticed some improvement in my overall energy and a touch of brightness under my eyes, but nothing life-changing. I’ll take what I can get, especially when it’s pre-portioned, well-packaged, and tastes this good.

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Best Liquid NAD Supplement: CoreMed Science NAD+ liquid supplement

Amazon

“Core Med Science’s NAD liquid supplement takes a smart approach with liposomal delivery, which means better absorption and potentially stronger results. I like that it’s non-GMO and free of artificial additives, showing a focus on purity,” noted Halland.

Most NAD supplements are offered in pill form, but CoreMed offers something else — a drinkable NAD liquid supplement. For people who struggle with taking pills, this could be a great option. Many customers agree that it tastes good, too.

“However, it’s a bit of a downside that the exact dosage isn’t clearly listed, and there’s not much info on third-party testing,” suggested Halland. “It’s a good pick if you’re looking for enhanced bioavailability, but a bit more transparency would be reassuring.”

Dose: N/A

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Best Budget-Friendly NAD: Double Wood Supplements NAD+

Amazon

“It’s all about high purity — you’re getting 95% pure NAD+, which is pretty impressive,” Halland pointed out.

Halland also likes that Double Woods Supplements NAD has third-party testing covered, “so it’s not just talk; there’s real transparency here.”

The price point is another major draw, although there may be some people seeking a more potent dose for their money.

“The dose is a nice starting point for boosting NAD+, though if you’re looking for a serious kick, you might need a bit more. Plus, it’s budget-friendly, which is a win if you’re trying to up your cellular health game without breaking the bank,” Halland added.

Dose: 500 mg NAD

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Best Organic NAD: Liposomal NR 300mg Nicotinamide Riboside Supplement

Amazon

Genuine Purity has claimed that its Liposomal Technology protects nutrients with a “bubble” that helps them reach the bloodstream for 80% more absorption. The brand also says it’s gentler on the stomach — ideal for people prone to digestive issues.

In addition to highlighting the Liposomal Technology, reviewers have also pointed out that Genuine Purity has helped boost their mood and energy levels a bit faster than they expected. While it may not give you an “explosion” of energy, consistent users may experience more vitality throughout the day and better quality sleep at night.

Using only organic and non-GMO ingredients, this made-in-America brand offers a cleaner option for anyone interested in boosting their overall health and mood.

Dose: 300 mg NR

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FAQ on NAD Supplements

The Post consulted two experts with direct experience with NAD supplements, Andrew Salzman and Registered Dietitian Caroline Thomason. We’ve also gathered publicly available insights from Mark Hyman.

What is NAD?

According to experts, NAD is an essential compound for keeping our cells healthy. NAD levels naturally decline as we age and are exposed to various stressors, from sun exposure to alcohol, overeating, and lack of sleep.

“One of the key longevity switches that regulates so many of the others is this pathway called sirtuins (a type of enzyme). And the key molecule that activates these is NAD. To get NAD, you have to increase the raw materials for it,” Hyman, who has taken Wonderfeel Youngr, explained.

What are some NAD supplement benefits?

As you age, NAD levels go down, but you can boost NAD levels by taking supplements that activate the sirtuin. Hyman explained some of the benefits of NAD supplements in an Instagram Live conversation with Baran Dilaver.

Hyman has listed a range of extraordinary benefits of NAD supplements: “DNA repair, helps you produce more energy in your cells, helps with exercise performance, lengthens your telomeres, helps with neurogenesis, making new brain cells, neuroplasticity, lowers inflammation, improves mitochondrial function, helps metabolism, your circadian rhythms, exercise performance.”

What is the difference between NMN, NR, and NAD Supplements?

We asked Salzman: “We know what NAD is, but what about NMN and NR?”

Salzman has explained that for NAD to work effectively, it must be inside the cell. However, NAD itself cannot cross cell membranes. The body creates NAD through a sequence, starting with NR and then NMN, which ultimately converts into NAD.

While NAD struggles to enter cells directly, NMN is different. The body has a specialized mechanism — a sort of “shuttle” — that recognizes NMN and allows it to pass through cell membranes more efficiently. Once inside the cell, NMN is converted into NAD, boosting energy and supporting cellular health. 

This makes NMN a highly effective precursor to NAD, and it’s why supplements like Wonderfeel focus on using NMN to elevate NAD levels efficiently.

How are NAD+ supplements different from other anti-aging supplements?

“Anti-aging is a broad area of nutrition supplements that can target everything from cognitive
function to skin health,” explained Thomason, who is a nutrition partner to Life Extension.

NAD+ supplementation differs from other anti-aging treatments in that it works at the cellular level.

“Unlike antioxidants or retinoids, which target surface-level issues like oxidative damage or skin aging, NAD+ supplements may address the internal/cellular causes of aging by improving energy and promoting cellular repair,” she said.

What are the best NAD+ supplements? How should you choose one?

Thomason explained that the FDA does not regulate supplements, but companies can still go through different processes to show a commitment to high standards.

Some NAD+ brands may have their ingredients reviewed by the FDA’s New Dietary Ingredient (NDI) notification program or recognized as Generally Recognized as Safe (GRAS), providing extra safety assurance and effectiveness.

“Look for third-party testing and certifications like NSF Certified for Sport, Alkemist Assured, or USP, which ensure the supplement’s potency, safety, and purity,” suggested Thomason.

“Good companies are transparent about their quality practices and provide certificates of analysis, allowing you to trace the product’s lab testing. Lastly, check for clinical research on the ingredients to confirm they are backed by peer-reviewed studies.”

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