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Real Madrid and Manchester City once again renew Champions League acquaintances after being paired together in the Round of 16.
City's 2-1 win at the Santiago Bernabeu in the league phase last December already marked the sixth time in the past seven seasons that the two clubs had faced one another in Europe's top competition.
Madrid's Clasico rivals also have Premier League opposition in the form of Newcastle United, who they beat 2-1 in their opening league phase game this term.
Liverpool similarly face a league phase rematch against Galatasaray, while Premier League counterparts Chelsea and Tottenham have tough assignments against holders Paris Saint-Germain and Atletico Madrid respectively.
Arsenal face Bayer Leverkusen and have avoided the prospect of a quarterfinal against City immediately before the clubs' potentially pivotal meeting at the Etihad Stadium on the weekend of April 18/19.
Surprise package Bodo/Glimt, who followed up wins over City and Atletico with victory in both legs of their knockout playoff against last season's finalists Inter Milan, will battle Sporting CP for a place in the quarterfinals.
MORE: Why do Bodo/Glimt have a slash? Name, location, squad worth of Norwegian club
Teams in UEFA Champions League knockouts
These are the 16 teams that qualified for the knockout phase.
Seeded teams are those who qualified for the Round of 16 directly via a top-eight finish in the league phase standings, while the unseeded teams are those who advanced through from the knockout-playoff round.
MORE: Can teams drop into Europa League from Champions League this season?
Seeded teams
| Club | Nation |
| Arsenal | England |
| Bayern Munich | Germany |
| Liverpool | England |
| Tottenham | England |
| Barcelona | Spain |
| Chelsea | England |
| Sporting CP | Portugal |
| Manchester City | England |
Unseeded teams
| Club | Nation |
| PSG | France |
| Galatasaray | Turkey |
| Real Madrid | Spain |
| Atalanta | Italy |
| Newcastle | England |
| Atletico Madrid | Spain |
| Bodo/Glimt | Norway |
| Bayer Leverkusen | Germany |
UEFA Champions League knockout phase: Draw result, bracket
Below is how the Champions League knockout schedule will look in 2025/26 following the draw in Switzerland.
The bracket is set from the Round of 16 onwards, meaning teams will know their possible opponents in the quarterfinals and semifinals should they progress.
For the quarterfinals and semifinals, the teams listed first in each fixture will play the first legs of those ties at home.
MORE: Updated top-scorer standings as Mbappe, Lewandowski chase golden boot
Round of 16
| Match No. | Fixture | 1st Leg | 2nd Leg | Aggregate Score |
| RO16 1 | PSG vs. Chelsea | 5-2 | _ | _ |
| RO16 2 | Galatasaray vs. Liverpool | 1-0 | _ | _ |
| RO16 3 | Real Madrid vs. Man City | 3-0 | _ | _ |
| RO16 4 | Atalanta vs. Bayern Munich | 1-6 | _ | _ |
| RO16 5 | Newcastle vs. Barcelona | 1-1 | _ | _ |
| RO16 6 | Atletico Madrid vs. Tottenham | 5-2 | _ | _ |
| RO16 7 | Bodo/Glimt vs. Sporting CP | 3-0 | _ | _ |
| RO16 8 | Leverkusen vs. Arsenal | 1-1 | _ | _ |
Quarterfinals
| Match No. | Fixture | 1st Leg | 2nd Leg | Aggregate Score |
| QF 1 | RO16 1 vs. RO16 2 | _ | _ | _ |
| QF 2 | RO16 3 vs. RO16 4 | _ | _ | _ |
| QF 3 | RO16 5 vs. RO16 6 | _ | _ | _ |
| QF 4 | RO16 7 vs. RO16 8 | _ | _ | _ |
Semifinals
| Match No. | Fixture | 1st Leg | 2nd Leg | Aggregate Socre |
| SF 1 | QF 1 vs. QF 2 | _ | _ | _ |
| SF 2 | QF 3 vs. QF 4 | _ | _ | _ |
Final
Champions League 2025/26 round dates
Round of 16
- 1st legs: March 10-11
- 2nd legs: March 17-18
Quarterfinals
- 1st legs: April 7-8
- 2nd legs: April 14-15
Semifinals
- 1st legs: April 28-29
- 2nd legs: May 5-6
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