Week 4 NFL score predictions, odds, picks, betting advice: Proven model locks in projections for every game

Make NFL best bets at NFL betting sites by seeing NFL score predictions from our advanced model

Oct 4, 2026 at 11:11 am ET • 4 min read

You can use the best sportsbook promos to earn up to $3,000 in sign-up bonuses from top betting apps for the loaded Week 4 NFL slate on Sunday. With star-studded showdowns like Cowboys vs. Texans, Rams vs. Eagles, Chiefs vs. Raiders and Broncos vs. 49ers set to unfold, you'll want to get the latest information before locking in your Week 4 NFL picks. According to the latest NFL odds, the Texans are favored by 2.5 points at home against the Cowboys, while the Raiders are 4.5-point underdogs against the Chiefs. 

The SportsLine Projection Model simplifies NFL betting with Week 4 NFL score predictions and NFL picks for all Week 4 NFL games by simulating each matchup 10,000 times. Bet on NFL Week 4 with the FanDuel promo code and get $250 in bonus bets:

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Bet on the NFL with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets:

Week 4 NFL betting promos and bonus codes 

Week 4 NFL score predictions

Sunday, Oct. 4

Commanders vs. Colts (-3.5), 9:30 a.m. ET

Score prediction: Colts 32, Commanders 27

SportsLine predicts that the Colts cover as 3.5-point favorites in 53% of simulations. Use the FanDuel promo code to get $250 in bonus bets for NFL games:

Giants vs. Cardinals (-1), 1 p.m. ET

Score prediction: Cardinals 25, Giants 23

SportsLine predicts that the Cardinals cover as 1-point favorites in 51% of simulations. Claim the Fanatics Sportsbook promo code here to get $350 in FanCash:

Texans (-2.5) vs. Cowboys, 1 p.m. ET

Score prediction: Texans 32, Cowboys 23

SportsLine predicts that the Texans cover as 2.5-point favorites in 66% of simulations. Bet on the NFL with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets:

Buccaneers vs. Packers (-4), 1 p.m. ET

Score prediction: Packers 23, Buccaneers 21

SportsLine predicts that the Bucs cover as 4-point underdogs in 54% of simulations. Claim the Caesars Sportsbook promo code CBSSPORTSBR250 and get up to $250 in bonuses as five days of $50 bet resets here:

Bengals (-2.5) vs. Jaguars, 1 p.m. ET

Score prediction: Jaguars 28, Bengals 27

SportsLine predicts that the Jaguars cover as 2.5-point underdogs in 55% of simulations. Claim $200 in bonus bets with a $10 bet by signing up for the bet365 promo code CBSBET365:

Eagles vs. Rams (-3), 1 p.m. ET

Score prediction: Rams 23, Eagles 21

SportsLine predicts that the Eagles cover as 3-point underdogs in 50% of simulations. Bet on the NFL by claiming the latest DraftKings promo code, where new users get $150 in bonus bets after your first $5 wager: 

Bills (-6.5) vs. Patriots, 1 p.m. ET

Score prediction: Bills 28, Patriots 20

SportsLine predicts that the Bills cover as 6.5-point favorites in 52% of simulations. Sign up at Hard Rock Bet and get $100 in bonus bets:

Bears (-3.5) vs. Jets, 1 p.m. ET

Score prediction: Bears 31, Jets 21

SportsLine predicts that the Bears cover as 3.5-point favorites in 67% of simulations. Use the FanDuel promo code to get $250 in bonus bets for NFL games:

Ravens (-11.5) vs. Titans, 1 p.m. ET

Score prediction: Ravens 34, Titans 20

SportsLine predicts that the Ravens cover as 11.5-point favorites in 56% of simulations. Claim the Caesars Sportsbook promo code CBSSPORTSBR250 and get up to $250 in bonuses as five days of $50 bet resets here:

Vikings (-11.5) vs. Dolphins, 4:05 p.m. ET

Score prediction: Vikings 32, Dolphins 15

SportsLine predicts that the Vikings cover as 11.5-point favorites in 66% of simulations. Bet on the NFL by claiming the latest DraftKings promo code, where new users get $150 in bonus bets after your first $5 wager: 

49ers (-2.5) vs. Broncos, 4:25 p.m. ET

Score prediction: 49ers 23, Broncos 21

SportsLine predicts that the Broncos cover as 2.5-point underdogs in 51% of simulations. Bet on the NFL with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets:

Raiders vs. Chiefs (-4.5), 4:25 p.m. ET

Score prediction: Chiefs 29, Raiders 21

SportsLine predicts that the Chiefs cover as 4.5-point favorites in 59% of simulations. Claim $200 in bonus bets with a $10 bet by signing up for bet365 Sportsbook with the promo code CBSBET365:

Seahawks (-7) vs. Chargers, 4:25 p.m. ET

Score prediction: Seahawks 29, Chargers 18

SportsLine predicts that the Seahawks cover as 7-point favorites in 58% of simulations. Claim the Fanatics Sportsbook promo code here to get $350 in FanCash:

Panthers vs. Lions (-3.5), 8:20 p.m. ET  

Score prediction: Lions 29, Panthers 26

SportsLine predicts that the Panthers cover as 3.5-point underdogs in 52% of simulations. Claim the Fanatics Sportsbook promo code here to get $350 in FanCash:

Monday, Oct. 5

Saints (-2.5) vs. Falcons, 8:15 p.m. ET

Score prediction: Saints 25, Falcons 24

SportsLine predicts that the Falcons cover as 2.5-point underdogs in 52% of simulations. Bet on the NFL by claiming the latest DraftKings promo code, where new users get $150 in bonus bets after your first $5 wager: 

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