Manchester City dominated the Premier League by claiming the title for four consecutive seasons (2020/21 to 2023/24). However, the English club's winning stride saw a drastic downfall in the 2024/25 campaign.
Man City concluded their run in the last season with a third-place finish in the Premier League and no major trophies.
Pep Guardiola has made some major additions to his squad in the ongoing summer transfer window, with reports suggesting that there are more to come.
While Guardiola & Co. will be looking to return to their winning ways in the upcoming 2025/26 season, there could be some significant fixtures that decide Man City's fate.
The Sporting News takes a look at the five league fixtures that could define Man City's upcoming league season.
Manchester United (Home) - September 13, 2025
The first Manchester Derby of the season is always a special one, more so if it is at the early stages of the Premier League campaign, as it provides a constructive analysis of both teams' respective forms.
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Man City are set to host Man United on September 13, and Guardiola's squad will be hoping to exhibit their dominance against their arch-rivals.
Both Manchester clubs have been pitted against each other in 56 Premier League matches so far, with United claiming 26 victories while City bagged 20 wins.
Arsenal (Away) - September 20, 2025

Man City and Arsenal's fight in the Premier League title race in recent seasons has been quite a regular event, with Guardiola mostly having the last laugh.
However, Mikel Arteta and Arsenal are not among those to back down, and City's first meeting with the Gunners in the 2025/26 Premier League season is definitely a crucial game.
Man City will face Arsenal on September 20, at the Emirates Stadium, where the former have managed seven wins out of their 28 away games.
Tottenham Hotspur (Away) - January 31, 2026
Man City has an underwhelming record against Tottenham Hotspur in the Premier League. The English clubs have faced each other in 56 league games, where Spurs have bagged 29 victories as opposed to City's 19 wins, and the remaining eight matches ended in a draw.
Man City have been able to manage only eight wins in their past 28 trips to Tottenham Hotspur Stadium, while Spurs have secured 17 victories at home.
Guardiola's squad will be looking for a win in their upcoming away match against Tottenham in the 2025/26 season.
Liverpool (Away) - February 7, 2026

Liverpool claimed the Premier League title last season and will be trying to defend their crown in the upcoming campaign as well.
Man City will face the reigning champions on February 7, 2026, at Anfield.
Liverpool have bagged 23 victories while Man City have managed 12 wins in 56 Premier League games, with the rest of the 21 matches ending in a tie.
Chelsea (Away) - April 11, 2026
While the past season might not have started in their favor in the beginning, Chelsea turned things around by the end with a fourth-place ranking in the Premier League table, claiming the Conference League and Club World Cup titles.
Being a relevant name in the 2025/26 Premier League title race, Man City's clash against Chelsea on April 11, 2026, at Stamford Bridge will be an important fixture for both sides.