George Clooney and Noah Wyle’s bromance: Then and Now

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George Clooney and Noah Wyle’s friendship goes back to the ’90s when they both starred in the medical drama “ER.” Despite the former leaving the show in 1999 to focus on a career in movies, Wyle gushed about their long-standing bond in recent interviews, calling him a “touchstone figure” in his life. The two recently reunited at the 2026 AARP Movies for Grownups Awards, where they presented each other with their respective awards. Clooney won best actor in a film for his role in “Jay Kelly,” while Wyle won the same award in the TV category for “The Pitt.” See how the two have evolved through the years.

Anthony Edwards as Doctor Mark Greene; George Clooney as Doctor Doug Ross; Noah Wyle as Doctor John Carter; Eriq La Salle as Doctor Peter Benton on E.R.

Anthony Edwards as Doctor Mark Greene, George Clooney as Doctor Doug Ross, Noah Wyle as Doctor John Carter and Eriq La Salle as Doctor Peter Benton on “ER.” NBCUniversal via Getty Images

Anthony Edwards, George Clooney, Noah Wyle, Eriq LaSalle in E.R.

Anthony Edwards, George Clooney, Noah Wyle and Eriq LaSalle in “ER.” ©NBC/Courtesy Everett Collection

Noah Wyle and George Clooney attend 5th Annual Fire and Ice Ball to Benefit Revlon UCLA Women Cancer Center on December 07, 1994.

Noah Wyle and George Clooney attend the 5th Annual Fire and Ice Ball to Benefit Revlon UCLA Women’s Cancer Center on Dec. 07, 1994. Ron Galella Collection via Getty Images

Courteney Cox, Noah Wyle, George Clooney, and Jennifer Aniston star in Friends in 1995.

Courteney Cox, Noah Wyle, George Clooney and Jennifer Aniston star in “Friends” in 1995. ©Warner Bros/Courtesy Everett Collection

Courteney Cox, Noah Wyle, and George Clooney in Friends in 1995.

Courteney Cox, Noah Wyle and George Clooney in “Friends” in 1995. ©Warner Bros/Courtesy Everett Collection

Sherry Stringfield, Noah Wyle, Julianna Margulies and George Clooney attend the 12th Annual Museum of Radio & Television Festival - "ER" Panel Discussion on March 4, 1995 in Los Angeles.

Sherry Stringfield, Noah Wyle, Julianna Margulies and George Clooney attend the 12th Annual Museum of Radio & Television Festival – “ER” Panel Discussion on March 4, 1995, in Los Angeles. Ron Galella Collection via Getty Images

Noah Wyle and actor George Clooney attend the "Desperado" Westwood Premiere on August 21, 1995 in Westwood, Calif.

Noah Wyle and George Clooney attend the “Desperado” Westwood premiere on Aug. 21, 1995, in Westwood, Calif. Ron Galella Collection via Getty Images

George Clooney and Noah Wyle attend the "From Dusk Till Dawn" Los Angeles Premiere on January 17, 1996.

George Clooney and Noah Wyle attend the “From Dusk Till Dawn” Los Angeles premiere on Jan. 17, 1996. Ron Galella Collection via Getty Images

George Clooney and Noah Wyle attend the 53rd Annual Golden Globe Awards on January 21, 1996.

George Clooney and Noah Wyle attend the 53rd Annual Golden Globe Awards on Jan. 21, 1996. WireImage

Noah Wyle and George Clooney arrive for the 48th Annual Emmy Awards on September 08, 1996.

Noah Wyle and George Clooney arrive for the 48th Annual Emmy Awards on Sept. 08, 1996. AFP via Getty Images

Noah Wyle, Julianna Margulies, and George Clooney at the 1996 premiere of HBO's Rebound in Los Angeles on September 07, 1996.

Noah Wyle, Julianna Margulies and George Clooney at the 1996 premiere of HBO’s “Rebound” in Los Angeles on Sept. 07, 1996. FilmMagic

Noah Wyle, Julianna Margulies, George Clooney, and Celine Balitran attend the "One Fine Day" Los Angeles Premiere on December 17, 1996.

Noah Wyle, Julianna Margulies, George Clooney and Celine Balitran attend the “One Fine Day” Los Angeles premiere on Dec. 17, 1996. WireImage

George Clooney, Anthony Edwards, Gloria Reuben, Noah Wyle and Laura Innes attend the Third Annual Screen Actors Guild Awards on February 23, 1997.

George Clooney, Anthony Edwards, Gloria Reuben, Noah Wyle and Laura Innes attend the Third Annual Screen Actors Guild Awards on Feb. 23, 1997. Ron Galella Collection via Getty Images

Noah Wyle and George Clooney at the 1998 Golden Globe Awards in Los Angeles.

Noah Wyle and George Clooney at the 1998 Golden Globe Awards in Los Angeles. FilmMagic, Inc

George Clooney pushes Noah Wyle on a swingset circa 1998 in Los Angeles.

George Clooney pushes Noah Wyle on a swingset circa 1998 in Los Angeles. Getty Images

From left, American actors Anthony Edwards, Noah Wyle, and George Clooney attend the opening night of 'Hello Again' at the Blank Theatre Company, Hollywood, California, April 17, 1998. (Photo by Ron Galella, Ltd./Ron Galella Collection via Getty Images)

Anthony Edwards, Noah Wyle and George Clooney at the Opening Night of ‘Hello Again’ on April 17, 1998, in Hollywood. Ron Galella Collection via Getty Images

George Clooney and Noah Wyle in 2000's "Fail Safe".

George Clooney and Noah Wyle in the 2000s “Fail Safe.” Courtesy Everett Collection

Brad Pitt, George Clooney, and Noah Wyle at Universal Studios on January 15, 2005.

Brad Pitt, George Clooney and Noah Wyle at Universal Studios on Jan. 15, 2005. WireImage

George Clooney and Noah Wyle pose for a portrait during the 2026 Annual Movies for Grownups Awards.

George Clooney and Noah Wyle pose for a portrait during the 2026 Annual Movies for Grownups Awards. Getty Images for AARP

George Clooney and Noah Wyle pose for a portrait during the 2026 Annual Movies for Grownups Awards.

George Clooney and Noah Wyle pose for a portrait during the 2026 Annual Movies for Grownups Awards. Getty Images for AARP

George Clooney and Noah Wyle pose for a portrait during the 2026 Annual Movies for Grownups Awards.

George Clooney and Noah Wyle pose for a portrait during the 2026 Annual Movies for Grownups Awards. Getty Images for AARP

George Clooney embraces Noah Wyle, as Wyle accepts the Best TV Actor award for 'The Pitt', at the AARP Movies for Grownups Awards in Beverly Hills, Calif. on January 10, 2026.

George Clooney embraces Noah Wyle, as Wyle accepts the best TV actor award for “The Pitt” at the AARP Movies for Grownups Awards in Beverly Hills, Calif., on Jan. 10, 2026. REUTERS

Noah Wyle accepts the Best TV Actor award for 'The Pitt', next to George Clooney, at the AARP Movies for Grownups Awards.

Noah Wyle accepts the best TV actor award for “The Pitt,” next to George Clooney, at the AARP Movies for Grownups Awards. REUTERS

Noah Wyle accepts the Best TV Actor award for 'The Pitt', next to George Clooney, at the AARP Movies for Grownups Awards.

Noah Wyle accepts the best TV actor award for “The Pitt,” next to George Clooney, at the AARP Movies for Grownups Awards. Getty Images for AARP

Noah Wyle reacts next to George Clooney, as Clooney accepts the Best Actor award for 'Jay Kelly', at the AARP Movies for Grownups Awards.

Noah Wyle reacts next to George Clooney, as Clooney accepts the best actor award for “Jay Kelly,” at the AARP Movies for Grownups Awards. REUTERS

Noah Wyle embraces George Clooney, as Clooney accepts the Best Actor award for 'Jay Kelly', at the AARP Movies for Grownups Awards.

Noah Wyle embraces George Clooney, as Clooney accepts the best actor award for “Jay Kelly,” at the AARP Movies for Grownups Awards. REUTERS

George Clooney, Myechia Minter-Jordan, Chief Executive Officer, AARP, and Noah Wyle attend the 2026 Annual Movies for Grownups Awards.

George Clooney, Myechia Minter-Jordan, Chief Executive Officer of AARP, and Noah Wyle attend the 2026 Annual Movies for Grownups Awards. Getty Images for AARP
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