Donor Support Powers New $15M Investment in 62 Scientists Tackling Alzheimer’s, Macular Degeneration, and Glaucoma

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Tracking Myelin and Alzheimer’s Blood Biomarkers to Explain Brain Lesions

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Matthias Hebisch, PhD,

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Massachusetts General Hospital (Mass General)

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Modeling Dementia in Brain Organoids with Alzheimer’s Disease

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Martin Hsu, PhD,

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University of North Carolina at Chapel Hill

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Uncovering a Protein in Astrocytes that Drives Alzheimer’s Disease

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Heidi Jacobs, PhD,

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Massachusetts General Hospital (Mass General)

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Dorsal Raphe Nucleus: Seam for Earliest Detection of Tau and Symptoms

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Selene Lomoio, PhD,

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Icahn School of Medicine at Mount Sinai

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A Human Platform to Decode Brain Changes in Alzheimer’s Disease

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Co-Principal Investigator: Valentina Fossati, PhD

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Amanda McQuade, PhD,

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University of California, San Francisco

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Understanding How Genetic Risk for Alzheimer’s Disease Impacts Immune Function

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Sarah Ocañas, PhD,

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Oklahoma Medical Research Foundation

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The Ovary-Brain Inflammatory Axis in Alzheimer’s Disease

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Co-Principal Investigator: Jeffrey Mason, PhD

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Daniel Panyard, PhD,

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Stanford University

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Identifying How Cardiovascular Disease Affects Risk of Alzheimer’s Disease

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Justin Perry, PhD,

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Memorial Sloan Kettering Cancer Center

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Does Fructose Drive Neurodegenerative Disease?

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Dominika Pilat, PhD,

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Massachusetts General Hospital (Mass General)

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A Nasal Route to Deliver RNA-Based Treatment for Alzheimer’s Disease

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Saima Rathore, PhD,

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Emory University

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AI-Informed Signature of Alzheimer’s Disease and Related Dementias to Model Longitudinal Disease Trajectories

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Co-Principal Investigators: Allan I. Levey, MD, PhD and Nicholas Seyfried, PhD

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Austin Reynolds, PhD

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, University of North Texas Health Science Center at Fort Worth

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Genetic Ancestry Impacts Mitochondrial Dysfunction in Alzheimer’s Disease

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Co-Principal Investigators: Nicole Phillips, PhD, and Robert Clinton Barber, PhD

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Leonardo Rivera- Rivera, PhD,

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University of Wisconsin-Madison

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Evaluating Cerebral Small Vessel Disease in Alzheimer’s with MRI

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Vladislava Segen, PhD

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, German Center for Neurodegenerative Diseases (Germany)

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Using Navigation to Detect Early Changes in Alzheimer’s Disease

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Gowoon Son, PhD,

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Mayo Clinic Jacksonville

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Why Alzheimer’s Disease Targets Some Cells First: A Driver in the Anterior Hypothalamus

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Vivek Swarup, PhD

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, University of California, Irvine

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Beyond Pathology: Mapping How Some Brains Stay Sharp in Extreme Old Age

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Christina Theodoris, MD, PhD

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, Gladstone Institutes

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Mapping How Brain Cells Change Over Aging to Predict Therapeutic Targets

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Tomas Vikner, PhD

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, University of Wisconsin-Madison

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Cerebrospinal Fluid Flow Dynamics in Alzheimer’s Disease

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Jennifer Sachiko Yokoyama, PhD

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, University of California, San Francisco

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Autoimmune Contributions to Alzheimer’s Disease

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Co-Principal Investigator: Joseph J. Sabatino, MD, PhD

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Keir Yong, PhD

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, University College London (U.K.)

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Visual System Vulnerability in Dementia: From Detection to Determinants

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Co-Principal Investigators: André Altmann, PhD and David M. Cash, PhD

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QI Zhang, PhD

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Emory University

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Uncovering New Early Detection Markers for Alzheimer’s Disease

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Haoyue Zhou, PhD

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, Gladstone Institutes

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How Blood Proteins Influence Brain Health and Alzheimer’s Disease

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Macular Degeneration Research

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Twenty million U.S. adults have

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—the leading cause of vision loss in Americans aged 65 and older. Early detection and treatment are crucial to slowing the disease progression and preventing permanent vision loss. Macular Degeneration Research grant recipients are exploring a wide range of innovative scientific approaches to prevent, treat, and cure macular degeneration—from developing novel methods to model AMD to investigating potential new treatments for both dry and wet AMD.

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2026 Macular Degeneration Research grant recipients:

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Ryoji Amamoto, PhD

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, Massachusetts Eye and Ear Infirmary (Harvard)

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Promoting Cone Survival in Dry AMD

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Marco Bassetto, PharmD, PhD

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,

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University of California, Irvine

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Development of a New Drug Delivery System to Treat Retinal Inflammation

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Celia Bisbach, PhD

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, University of Wisconsin-Madison

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Targeting and Removing Harmful Proteins to Treat Wet AMD

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Suman Chaudhary, PhD

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, Schepens Eye Research Institute of Mass. Eye and Ear

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A Novel Antioxidant Therapy for Age-Related Macular Degeneration

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Mark Draelos, MD, PhD

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, University of Michigan

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Studying Eye Blood Flow During Exercise Stress Tests

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Anaïs Françon , PhD

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, Hôpital Maisonneuve-Rosemont (Canada)

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Role of Lack of Sleep in Blood Vessel Formation in Retinal Degeneration

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Petra Larsen, MD, PhD

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, German Center for Neurodegenerative Diseases (Germany)

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Mapping the Molecular-Imaging Interface in AMD: A Multimodal Approach

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Eric (Xiang) Ma, PhD

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, Oklahoma Medical Research Foundation

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Protecting Choroidal Blood Vessels to Prevent Vision Loss in AMD

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Jason Miller, MD, PhD

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, University of Michigan

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RPE Lipid Degradation and Secretion in Age-Related Macular Degeneration

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Sarah Palko, PhD

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, Trinity College Dublin (Ireland)

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Understanding How Müller Glia Contribute to Immune Cell Accumulation in AMD

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Estelle (Sunghee) Park, PhD

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, Purdue University

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Uncovering the Hidden Link Between Liver Health and Macular Degeneration

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Amir Vahabikashi, PhD

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, Northeastern University

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Human Retina-on-a-Chip: A Next-Generation Model for Age-Related Macular Degeneration

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David Veysset, PhD

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, Massachusetts General Hospital (Harvard)

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Advancing AMD Diagnosis with Novel Spectroscopic Tools

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Lily (Wenjing) Wu, PhD

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, University of Oklahoma Health Sciences Center

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Targeting Age-Related Vision Loss with the Power of Essential Fats

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National Glaucoma Research

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Around 4 million U.S. adults have

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—a leading cause of blindness in the U.S. caused by damage to the optic nerve. Because there are often no early symptoms, as many as half of those affected may not even know they have it until irreversible vision loss has occurred. Early detection and treatments can help slow the disease’s progression.

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National Glaucoma Research grant recipients are investigating a wide range of scientific approaches, including leveraging artificial intelligence to promote earlier detection and better identify who’s most at risk, developing novel treatments, and exploring ways to protect and regenerate the optic nerve that could restore vision.

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2026 National Glaucoma Research grant recipients:

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Navid Amini, PhD

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, California State University, Los Angeles

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How Glaucoma Patients Lift Their Feet and Use Smart Insoles to Walk Safely

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Revathi Balasubramanian, PhD

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, Columbia University

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How Schlemm’s Canal Develops and What Goes Awry in Pediatric Glaucoma

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Evan Cameron, PhD

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, Cleveland Clinic – Lerner Research Institute

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Understanding Astrocyte-Immune Cell Signaling in Glaucoma

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Mark Christopher, PhD

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, University of California, San Diego

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Agentic Multimodal AI System for Glaucoma Management

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Qi Cui, MD, PhD

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, University of Pennsylvania, Perelman School of Medicine

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Myeloid Cellular Responses in Hypertensive Glaucoma

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Luca Della Santina, PhD, PharmD

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, University of Houston

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Using AI to Detect Loss of Connections Between Cells in the Eye

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Stuart Gardiner, PhD

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, Good Samaritan Foundation (Legacy Health System)

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Measuring the Effects of Visual Stimuli on Retinal Blood Vessels and Flow

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