Buccaneers vs 49ers projected starting lineup and depth chart for Week 6 | 2025 NFL season

After an action-packed win against the Los Angeles Rams on Thursday in Week 5, the San Francisco 49ers are now set to face another top NFC side on the road in Week 6. The Niners will battle it out with the Buccaneers in a late-afternoon game at Tampa Bay on Sunday.

The Bucs will have another chance to prove themselves against another NFC West juggernaut in their Week 6 matchup after defeating the Seattle Seahawks 38-35 last week.

With the 49ers and Bucs both 4-1 on the season entering this game, they will be vying for the top spot in the NFC after the Philadelphia Eagles dropped to 4-2 following a loss to the New York Giants on Thursday.

Here, we will take a look at both sides' projected starting lineups ahead of the much-anticipated NFC matchup.

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Tampa Bay Buccaneers vs. San Francisco 49ers projected starting lineup for Week 6

Tampa Bay Buccaneers projected starting lineup

Quarterback Baker Mayfield of the Tampa Bay Buccaneers - NFL 2025 - Source: Getty

Below is how the Tampa Bay Buccaneers are projected to line up on offense to start the game against the San Francisco 49ers:

Below is how the Tampa Bay Buccaneers could likely line defensively against the 49ers on Sunday:

Below is how the Bucs' special teams are projected to line up to start the game against the 49ers:

San Francisco 49ers projected starting lineup

Running back Christian McCaffrey of the San Francisco 49ers - Source: Getty

Below is how the 49ers are projected to line up on offense to start the game against the Bucs:

Below is how the Niners are projected to line up defensively to start the game against the Bucs:

Below is how the 49ers' special teams are projected to line up to start the game against the Buccaneers:

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Tampa Bay Buccaneers vs. San Francisco 49ers depth chart

Tampa Bay Buccaneers depth chart

Below is a look at the Bucs’ offensive depth chart:

Below is a look at the Bucs’ defensive depth chart:

Below is a look at the Bucs’ special teams depth chart:

San Francisco 49ers depth chart

Below is a look at the 49ers’ offensive depth chart:

Below is a look at the 49ers’ defensive depth chart:

Below is a look at the Niners’ special teams depth chart:

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How to watch the Bucs vs. 49ers Week 6 game? TV schedule and live stream details

The San Francisco 49ers are scheduled to face the Tampa Bay Buccaneers on Sunday, Oct. 12, at 4:25 p.m. ET at Raymond James Stadium. This game is the 49ers' second consecutive road game, and they will be looking to record a win, like they did in the Week 5 game at SoFi Stadium.

This game represents the 29th time the 49ers and the Bucs will face off in the NFL. San Francisco has won 21 of the first, while Tampa Bay has only recorded seven wins in this series.

CBS will broadcast the all-NFC game, with play-by-play commentator Jim Nantz, in-game analyst Tony Romo, and sideline reporter Tracy Wolfson providing commentary.

Game details:

Date and Time: Sunday, Oct. 12 at 4:25 p.m. ET

Location: Raymond James Stadium in Tampa Bay, Florida

TV: CBS

Announcers: Jim Nantz (play-by-play), Tony Romo (color analyst), Tracy Wolfson (color analyst)

Live Streaming: FuboTV, DirecTV Stream, NFL+, Hulu+ Live TV, YouTube TV

Edited by Ribin Peter